Genetic quirk in people from isolated Cretan villages is found to protect them against deadly heart disease

People living in isolated Cretan mountains villages live long and healthy lives thanks to a unique gene that protects them against heart disease, scientists have discovered.

Researchers studied the villagers in an area of northern Crete because they had low cases of heart disease despite eating lots of animal fats.

The study, for the first time made a genetic portrait of the population of  Zoniana and Anogia by sequencing the entire genome of 250 individuals.

They found a new genetic variant, common among villagers, which appears to protect the heart by lowering levels of ‘bad’ fats and cholesterol.

Researchers from the Wellcome Trust Sanger Institute found that the variant is 40 times more common in this small Greek population than in other European populations.

Lead author, Professor Eleftheria Zeggini said: ‘Genetic studies like this can help us begin to understand why this is.’

The team used the results to give a more detailed view of approximately 3,200 people for whom previous genetic information was known.

Heart disease is associated with a build-up of fatty deposits inside the arteries and an increased risk of blood clots.

One of the main causes of death and disability in the UK, it can cause damage to arteries in organs such as the brain, heart, kidneys and eyes.

The villagers were found to get type 2 diabetes at the same rate as the general Greek population, but they do not appear to suffer from the usual complications of the disease, such as diabetic kidney disease. 

It discovered four separate genetic variants that affect diastolic blood pressure, fasting glucose levels, white blood cell count and haemoglobin levels.

Professor Zeggini said: ‘This study shows the importance of looking at the entire genome to better understand the genetic architecture of a population..

‘We are finding new genetic variants we haven’t seen before.

‘We have discovered a medically relevant genetic variant for traits related to cardiovascular disease, the most common cause of death worldwide.’

The findings were published in Nature Communication.

Daily Mail

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